Cell type markers indicate distinct contributions of decidual stromal cells and natural killer cells in preeclampsia. Issue 5 (17th October 2022)

• Record Type: Journal Article
• Authors: Rytkönen, Kalle T; Adossa, Nigatu; Mahmoudian, Mehrad; Lönnberg, Tapio; Poutanen, Matti; Elo, Laura L
• Is Part Of: Reproduction. Volume 164:Issue 5(2022)
• Page Start: V9
• Page End: V13
• Publication Date: 2022-10-17
• Subjects: Reproduction -- Periodicals; Reproduction -- Molecular aspects -- Periodicals; Reproduction -- Immunological aspects -- Periodicals; Reproduction -- Endocrine aspects -- Periodicals; Fertility -- Periodicals; Human reproduction -- Periodicals; 571.805
• DOI: 10.1530/REP-22-0079
• Languages: English
• ISSNs: 1470-1626

Abstract

Abstract : In brief: Preeclampsia is a common serious disorder that can occur during pregnancy. This study uses integrative analysis of preeclampsia transcriptomes and single-cell transcriptomes to predict cell type-specific contributions to preeclampsia. Abstract: Preeclampsia is a devastating pregnancy disorder and a major cause of maternal and perinatal mortality. By combining previous transcriptomic results on preeclampsia with single-cell sequencing data, we here predict distinct and partly unanticipated contributions of decidual stromal cells and uterine natural killer cells in early- and late-onset preeclampsia.