Discovery of β-ionone derived chalcones as potent anti-aging agents. (February 2023)

• Record Type: Journal Article
• Authors: Wang, Yanyan; Fan, Xinrong; Zhang, Jianxia; Ye, Yanfei; Xing, Sunhui; Zhu, Qianqian; Yang, Huamao; Ni, Zefeng; Wang, Kun; Jiang, Chengxi
• Is Part Of: Phytochemistry letters. Volume 53(2023)
• Page Start: 211
• Page End: 215
• Publication Date: 2023-02
• Subjects: β-ionone -- Antioxidant -- Anti-aging -- Drosophila; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2023.01.001
• Languages: English
• ISSNs: 1874-3900

Abstract

Abstract: The accumulation of free radicals and consequent oxidative stress are primary drivers of aging. As such, antioxidants that eliminate free radicals may achieve anti-aging effects. To develop an anti-aging antioxidant, systematic structural modifications were carried out, with β-ionone as the lead. Subsequently, compound 5d was identified as the most active antioxidant. The novel compound 5d exhibited excellent free radical-scavenging ability in vitro, and improved the athletic ability and lifespan of Drosophila in vivo. The extension of lifespan due to 5d may be associated with inhibition of malondialdehyde (MDA) and an increase in the activity of catalase (CAT) and superoxide dismutase (SOD). These results suggest that 5d represents a promising anti-aging agent, thus worthy of further investigation. Graphical Abstract: A series of novel β-ionone derivatives were synthesized and evaluated their antioxidant and anti-aging activity in vitro and in vivo. ga1 Highlights: A series of novel β-ionone derivatives were designed and synthesized. 5d was the most potent compound with excellent free radical-scavenging ability. 5d prolong the survival rate and lifespan of Drosophila. 5d could be a potential lead compound of antioxidant and anti-aging agent.