Fabrication and Bioactivity of Peptide‐Conjugated Biomaterial Tissue Engineering Constructs. Issue 1 (24th July 2022)

• Record Type: Journal Article
• Authors: Nun, Nicholas; Joy, Abraham
• Other Names: Liu Tianbo guestEditor.; Cavicchi Kevin guestEditor.; Li Yiwen guestEditor.; Yin Panchao guestEditor.
• Is Part Of: Macromolecular rapid communications. Volume 44:Issue 1(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-07-24
• Subjects: Macromolecules -- Periodicals; Polymers -- Periodicals; Chemistry -- Periodicals; 547.705
• DOI: 10.1002/marc.202200342
• Languages: English
• ISSNs: 1022-1336

Abstract

Abstract: Tissue engineering combines materials engineering, cells and biochemical factors to improve, restore or replace various types of biological tissues. A nearly limitless combination of these strategies can be combined, providing a means to augment the function of a number of biological tissues such as skin tissue, neural tissue, bones, and cartilage. Compounds such as small molecule therapeutics, proteins, and even living cells have been incorporated into tissue engineering constructs to influence biological processes at the site of implantation. Peptides have been conjugated to tissue engineering constructs to circumvent limitations associated with conjugation of proteins or incorporation of cells. This review highlights various contemporary examples in which peptide conjugation is used to overcome the disadvantages associated with the inclusion of other bioactive compounds. This review covers several peptides that are commonly used in the literature as well as those that do not appear as frequently to provide a broad scope of the utility of the peptide conjugation technique for designing constructs capable of influencing the repair and regeneration of various bodily tissues. Additionally, a brief description of the construct fabrication techniques encountered in the covered examples and their advantages in various tissue engineering applications is provided. Abstract : Various fabrication techniques can be used to form tissue engineering constructs. These constructs can be conjugated with peptides in a straightforward fashion providing them with bioactivity. Peptides afford distinct advantages over other techniques for imparting bioactivity making peptide‐conjugated constructs excellent candidates to improve healing outcomes in a multitude of tissue engineering applications.