Pacemaker activity and ion channels in the sinoatrial node cells: MicroRNAs and arrhythmia. (January 2023)

• Record Type: Journal Article
• Authors: Fan, Wei; Sun, Xuemei; Yang, Chao; Wan, Juyi; Luo, Hongli; Liao, Bin
• Is Part Of: Progress in biophysics and molecular biology. Volume 177(2023)
• Page Start: 151
• Page End: 167
• Publication Date: 2023-01
• Subjects: Sinoatrial node -- MicroRNAs -- Ion channels -- Arrhythmias -- Action potential; Biophysics -- Periodicals; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular Biology -- Periodicals; Biophysique -- Périodiques; Biochimie -- Périodiques; 571.4
• DOI: 10.1016/j.pbiomolbio.2022.11.005
• Languages: English
• ISSNs: 0079-6107

Abstract

Abstract: The primary pacemaking activity of the heart is determined by a spontaneous action potential (AP) within sinoatrial node (SAN) cells. This unique AP generation relies on two mechanisms: membrane clocks and calcium clocks. Nonhomologous arrhythmias are caused by several functional and structural changes in the myocardium. MicroRNAs (miRNAs) are essential regulators of gene expression in cardiomyocytes. These miRNAs play a vital role in regulating the stability of cardiac conduction and in the remodeling process that leads to arrhythmias. Although it remains unclear how miRNAs regulate the expression and function of ion channels in the heart, these regulatory mechanisms may support the development of emerging therapies. This study discusses the spread and generation of AP in the SAN as well as the regulation of miRNAs and individual ion channels. Arrhythmogenicity studies on ion channels will provide a research basis for miRNA modulation as a new therapeutic target. Graphical abstract: Graphical Abstract: Potential antiarrhythmic of MicroRNAs (MiRNAs). Image 1