Composite measures of motor performance and self-efficacy are better determinants of postural instability and gait difficulties than individual clinical measures in Parkinson's disease. (February 2023)

• Record Type: Journal Article
• Authors: Pongmala, Chatkaew; Roytman, Stiven; van Emde Boas, Miriam; Dickinson, Olivia; Kanel, Prabesh; Bohnen, Nicolaas I.
• Is Part Of: Parkinsonism & related disorders. Volume 107(2023)
• Publication Date: 2023-02
• Subjects: Parkinson's disease -- Periodicals; Movement disorders -- Periodicals; Movement Disorders -- Periodicals; Nerve Degeneration -- Periodicals; Nervous System Diseases -- Periodicals; Parkinson Disease -- Periodicals; Tremor -- Periodicals; Parkinson, Maladie de -- Périodiques; Parkinson's disease; 616.833
• DOI: 10.1016/j.parkreldis.2022.105251
• Languages: English
• ISSNs: 1353-8020

Abstract

Abstract: Background: Postural instability and gait difficulties (PIGD) are a significant cause of disability and loss of quality of life (QoL) in Parkinson's Disease. Most research on clinical predictors of PIGD measures have focused on individual clinical often motor performance variables, However, PIGD motor features often result in fear of falling (FoF) lowering a patient's mobility self-efficacy. The purpose of this study was to assess composite measures of motor and self-efficacy determinants PIGD motor features in PD and compare these to analysis of individual clinical metrics. Methods: 75 PD participants underwent detailed motor and non-motor test batteries. Principal component analysis (PCA) was used to identify clusters of covarying correlates of slow walking, imbalance, falls, freezing of gait, FoG and compare these to traditional univariate analyses. Results: A single PCA-derived composite measure of motor performance and self-efficacy of mobility was the most robust determinant of all PIGD motor features except for falls. In contrast, analysis of the individual clinical variables showed more limited and diverging findings, including evidence of better cognitive performance but more severe motor parkinsonian ratings in the fall group. Conclusion: There are robust associations between composite measures of motor performance and self-efficacy of mobility and all PIGD motor features except for falls. Univariate analysis of individual clinical measures showed limited correlates of PIGD motor features. Patient's own perception of motor performance, FoF, and QoL deserve more attention as PIGD therapeutic targets in PD. Highlights: Composite measures of motor performance and self-efficacy are better determinants of PIGD than individual clinical measures in PD. Increasing relevance of not only motor severity but also compromised self-efficacy of mobility functions with advancing PD. Measures of fear of falling are robust determinants of PIGD motor features. Patient's own perception of motor performance, fear of falling, and quality of life deserve more attention as PIGD therapeutic targets in PD.