Crosstalk between Mu-Opioid receptors and neuroinflammation: Consequences for drug addiction and pain. (February 2023)

• Record Type: Journal Article
• Authors: Cuitavi, Javier; Torres-Pérez, Jose Vicente; Lorente, Jesús David; Campos-Jurado, Yolanda; Andrés-Herrera, Paula; Polache, Ana; Agustín-Pavón, Carmen; Hipólito, Lucía
• Is Part Of: Neuroscience and biobehavioral reviews. Volume 145(2023)
• Publication Date: 2023-02
• Subjects: Akt Protein Kinase B -- CFA Complete Freund's Adjuvant -- CNS Central Nervous System -- DAMGO (D-Ala2, N-MePhe4, Gly-ol)-enkephalin -- DOR Delta Opioid Receptor -- ERK Extracellular signal-regulated Kinase -- GRK2 G Protein-coupled Receptor Kinase 2 -- i.p. Intraperitoneal -- IKKs IKappaB Kinases -- IL Interleukin -- JNK c-Jun NH2-Terminal Kinase -- KOR Kappa Opioid Receptor -- LPS Lipopolysaccharide -- MAPK Mitogen-Activated Protein Kinase -- MCLS Mesocorticolimbic System -- MEK Mitogen-Activated Protein Kinase Kinase -- MORs Mu-Opioid Receptors -- mRNA Messenger Ribonucleic Acid -- NAc Nucleus Accumbens -- NF-kB Nuclear Factor Kappa B -- NKR1 Neurokinin Receptor 1 -- OIH Opioid Induced Hyperalgesia -- ORL1 Opioid Receptor like-1 -- ORs Opioid Receptors -- PFC Prefrontal Cortex -- PKC Protein Kinase C -- ROS Reactive Oxygen Species -- siRNA Small interfering RNA -- SNPs Single Nucleotide Polymorphisms -- TLRs Toll-like Receptors -- TNF-α Tumour Necrosis Factor alpha -- VTA Ventral Tegmental Area; Opioid signaling -- Neuroimmunity -- Reinforcement -- Nociception; Psychophysiology -- Periodicals; Human behavior -- Periodicals; Animal behavior -- Periodicals; Neurology -- Periodicals; Behavior -- Periodicals; Ethology -- Periodicals; Neurology -- Periodicals; Psychophysiologie -- Périodiques; Comportement humain -- Périodiques; Animaux -- Mœurs et comportement -- Périodiques; Neurologie -- Périodiques; Animal behavior; Human behavior; Neurology; Psychophysiology; Periodicals; Electronic journals; 573.8
• DOI: 10.1016/j.neubiorev.2022.105011
• Languages: English
• ISSNs: 0149-7634

Abstract

Abstract: Mu-Opioid Receptors (MORs) are well-known for participating in analgesia, sedation, drug addiction, and other physiological functions. Although MORs have been related to neuroinflammation their biological mechanism remains unclear. It is suggested that MORs work alongside Toll-Like Receptors to enhance the release of pro-inflammatory mediators and cytokines during pathological conditions. Some cytokines, including TNF-α, IL-1β and IL-6, have been postulated to regulate MORs levels by both avoiding MOR recycling and enhancing its production. In addition, Neurokinin‐1 Receptor, also affected during neuroinflammation, could be regulating MOR trafficking. Therefore, inflammation in the central nervous system seems to be associated with altered/increased MORs expression, which might regulate harmful processes, such as drug addiction and pain. Here, we provide a critical evaluation on MORs' role during neuroinflammation and its implication for these conditions. Understanding MORs' functioning, their regulation and implications on drug addiction and pain may help elucidate their potential therapeutic use against these pathological conditions and associated disorders. Highlights: Mu-Opioid receptors (MORs) are drivers of neuroinflammation when activated. Cytokines regulate MORs expression and probably trafficking. The MORs-neuroinflammation crosstalk conditions relapse and addictive behaviors. Alterations in cytokines production and Mu-Opioid receptors modulate pain.