FIMICS: A panel of long noncoding RNAs for cardiovascular conditions. Issue 1 (January 2023)

• Record Type: Journal Article
• Authors: Firat, Huseyin; Zhang, Lu; Baksi, Shounak; Leszek, Przemyslaw; Schordan, Eric; Ounzain, Samir; Kottwitz, Jan; Patriki, Dimitri; Heidecker, Bettina; Lüscher, Thomas F.; Pedrazzini, Thierry; Devaux, Yvan
• Is Part Of: Heliyon. Volume 9:Issue 1(2023)
• Publication Date: 2023-01
• Subjects: Biomarker -- Heart failure -- Cardiovascular condition -- Long-noncoding RNA -- Deep RNA sequencing -- Cardiac enriched RNA; Research -- Periodicals; Medical sciences -- Periodicals; Natural history -- Periodicals; Social sciences -- Periodicals; Earth sciences -- Periodicals; Physical sciences -- Periodicals; 507.2
• DOI: 10.1016/j.heliyon.2023.e13087
• Languages: English
• ISSNs: 2405-8440

Abstract

Summary: Cardiovascular disorders such as heart failure are leading causes of mortality. Patient stratification via identification of novel biomarkers could improve management of cardiovascular diseases of complex etiologies. Long-noncoding RNAs (lncRNAs) are highly tissue-specific in nature and have emerged as important biomarkers in human diseases. In this study, we aimed to identify cardiac-enriched lncRNAs as potential biomarkers for cardiovascular conditions. Deep RNA sequencing and quantitative PCR identified differentially expressed lncRNAs between failing and non-failing hearts. An independent dataset was used to evaluate the enrichment of lncRNAs in normal hearts. We identified a panel of 2906 lncRNAs, named FIMICS, that were either cardiac-enriched or differentially expressed between failing and non-failing hearts. Expression of lncRNAs in blood samples differentiated patients with myocarditis and acute myocardial infarction. We hereby present the FIMICS panel, a readily available tool to provide insights into cardiovascular pathologies and which could be helpful for diagnosis, monitoring and prognosis purposes.