The potential utility of anterior upper lobe honeycomb-like lesion in interstitial lung disease associated with connective tissue disease. (October 2020)

• Record Type: Journal Article
• Authors: Yamakawa, Hideaki; Ogura, Takashi; Sato, Shintaro; Nishizawa, Tomotaka; Kawabe, Rie; Oba, Tomohiro; Kato, Akari; Horikoshi, Masanobu; Akasaka, Keiichi; Amano, Masako; Kuwano, Kazuyoshi; Sasaki, Hiroki; Baba, Tomohisa; Matsushima, Hidekazu
• Is Part Of: Respiratory medicine. Volume 172(2020)
• Publication Date: 2020-10
• Subjects: Anterior upper lobe honeycomb-like lesion -- Interstitial lung disease -- Connective tissue disease -- Rheumatoid arthritis; Chest -- Diseases -- Periodicals; Chest -- Diseases -- Great Britain -- Periodicals; Respiratory organs -- Diseases -- Periodicals; Respiratory Tract Diseases -- Periodicals; Appareil respiratoire -- Maladies -- Périodiques; Thorax -- Maladies -- Périodiques; Appareil respiratoire -- Maladies -- Traitement -- Périodiques; Electronic journals; 616.2
• DOI: 10.1016/j.rmed.2020.106125
• Languages: English
• ISSNs: 0954-6111

Abstract

Abstract: Background: Interstitial lung disease (ILD) is associated with high morbidity and mortality in patients with connective tissue disease (CTD). Because some patients with CTD overlap present with ILD first, with CTD diagnosed later, specific radiologic signs are needed to help differentiate each CTD or CTD-ILD from idiopathic ILD. Objectives: To determine whether specific CT findings can help differentiate CTD as rheumatoid arthritis (RA), systemic sclerosis (SSc), or polymyositis/dermatomyositis (PM/DM). Methods: We analyzed 143 consecutive ILD patients with RA, SSc, or PM/DM. We assessed diagnostic accuracy of CT findings of CTD-ILD, CT pattern, and signs including "anterior upper lobe honeycomb-like lesion" and "low attenuation area (LAA) within an interstitial abnormality" for each CTD-ILD. Prognostic predictors were determined using Cox regression models. Results: Subjects were 78 patients with RA-ILD, 38 with SSc-ILD, 24 with PM/DM-ILD, and 3 with overlapping CTD-ILD. High frequency of anterior upper lobe honeycomb-like lesion suggests that CTD-ILD is due to RA-ILD (22%) rather than SSc-ILD (8%) or PM/DM-ILD (8%), whereas LAA within an interstitial abnormality suggests that CTD-ILD is due to SSc-ILD (26%) rather than RA-ILD (4%) or PM/DM-ILD (0%). Multivariate analysis showed that while not associated with survival, current or ex-smoker, honeycombing, and acute exacerbation were negative prognostic factors of mortality. Conclusions: The tendency is high for RA-ILD, in which anterior upper lobe honeycomb-like lesion is a specific feature, to show UIP or NSIP/UIP pattern, combined emphysema, and honeycombing; SSc-ILD to show NSIP pattern and LAA within an interstitial abnormality; and PM/DM-ILD to show NSIP pattern and non-honeycombing. Highlights: Specific radiologic signs may need to help differential diagnosis of ILDs. Anterior upper lobe honeycomb-like lesion may be an indicative predictor of RA-ILD. LAA within an interstitial abnormality may be a specific feature of SSc-ILD.