Primary Ewing sarcoma of the kidney: a symptomatic presentation and review of the literature. (June 2013)

• Record Type: Journal Article
• Authors: Hakky, Tariq S.; Gonzalvo, Americo A.; Lockhart, Jorge L.; Rodriguez, Alejandro R.
• Is Part Of: Therapeutic advances in urology. Volume 5:Number 3(2013)
• Page Start: 153
• Page End: 159
• Publication Date: 2013-06
• Subjects: Ewing sarcoma -- partial nephrectomy -- primitive neuroectoderm tumors -- renal -- renal Ewing sarcoma; Urology -- Periodicals; Urologic Diseases -- therapy -- Periodicals; Genital Diseases, Male -- therapy -- Periodicals; Urologie -- Périodiques; 616.6005
• DOI: 10.1177/1756287212471095
• Languages: English
• ISSNs: 1756-2872

Abstract

The objective of this review is to discuss the unique nature of primary renal Ewing sarcoma, including incidence, presentation and management. We also report on a common pattern of presentation, consisting of acute flank pain mimicking a renal stone colic, with or without hydronephrosis, and a renal mass discovered during imaging studies of renal Ewing sarcoma. We present our case of renal Ewing sarcoma along with imaging and pathological analysis. We also performed a retrospective review of all cases of renal Ewing sarcoma using PubMed. A total of 48 cases of renal EWS sarcoma have been reported and analyzed in this review. A mean age of 30.4 years was found along with a 61% male predominance. The mean survival was 26.14 months with a lower median survival in patients with advanced metastatic disease. Primary Ewing sarcoma of the kidney is rare. The diagnosis of primary renal EWS can be difficult and is based on a combination of electron microscopy, immunohistochemistry, chromosomal analysis, fluorescence in situ hybridization (FISH) and light microscopy.