Bacteria-driven bio-therapy: From fundamental studies to clinical trials. (February 2023)

• Record Type: Journal Article
• Authors: Yu, Yuxuan; Lin, Sicen; Chen, Zhichao; Qin, Bin; He, Zhonggui; Cheng, Maosheng; Sun, Mengchi; Sun, Jin
• Is Part Of: Nano today. Volume 48(2023)
• Publication Date: 2023-02
• Subjects: Natural bacteria -- Genetic engineering -- Synthetic materials modification -- Hybrid bacteria -- Bacteria-driven bio-therapy; Nanotechnology -- Periodicals; Nanosciences -- Périodiques; 620.505
• DOI: 10.1016/j.nantod.2022.101731
• Languages: English
• ISSNs: 1748-0132

Abstract

Abstract: Natural bacteria have been utilized to directly maintain the human body's homeostasis for directly or indirectly relieving diseases throughout history. With the rapid development of genetic engineering and synthetic materials modification, the recent era has witnessed numerous hybrid bacteria designed to meet the clinical requirements with expanded functionality in treating dozens of diseases, including obesity, gastrointestinal disorders, and even cancers. This review outlined the characteristics and applications of natural bacteria-based drugs in treating different disease conditions and summarized different conjugation methods of hybrid bacteria and their fate in vivo through multiple administration routes. Moreover, therapeutic bacteria-based complex disease treatments were also discussed to reveal the importance and feasibility of these biotherapeutics. Finally, the challenges in the clinical applications of bacterial drugs were discussed. The current review further highlighted the forward-looking solution strategies for bacterial bio-therapy to accelerate its clinical usage. Graphical abstract: Schematic representation bacteria-driven bio-therapy for curing refractory diseases at pre-clinical and clinical level. (A) Fundamental Studies: outline the therapeutic applications of various natural bacteria and summarize the preparation methods of hybrid bacteria, including genetic engineering, polymer coating, anchorage approach and endocytosis. (B) Clinical Trials: highlight the clinical applications for curing refractory diseases. ga1 Highlights: Emphasizing the characteristics and applications of natural bacteria-based drugs in treatment. Summarizing different conjugations of hybrid bacteria and their in vivo fate via multiple administration routes. Comprehensively reviewing the clinical applications of bacterial drugs and discussing the challenges of bacterial drugs.