IL-23 Gene Expression in PBMCs of Patients with Coronary Artery Disease. Issue 6 (21st May 2013)

• Record Type: Journal Article
• Authors: Khojasteh-Fard, Maryam; Abolhalaj, Milad; Amiri, Parvin; Zaki, Majid; Taheri, Zahra; Qorbani, Mostafa; Bazzaz, Javad Tavakkoly; Amoli, Mahsa M.
• Is Part Of: Disease markers. Volume 33:Issue 6(2012)
• Page Start: 289
• Page End: 293
• Publication Date: 2013-05-21
• Subjects: Cytokine -- gene -- expression -- CAD -- IL-23; Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.3233/DMA-2012-00933
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : Objective: Both adaptive and innate immune systems are involved in coronary artery disease (CAD). The aim of this study was to evaluate TH17 cytokines expression profiles in un-stimulated peripheral blood lymphocytes (PBMCs) of patients with coronary artery disease. Methods: Expression profiles of IL-17, IL-23, and TGF-β1 were determined in individuals with and without CAD using Real-time PCR. Results: A significant decrease in IL-23 gene expression in un-stimulated PBMCs of patients with CAD compared to those without CAD was found (p=0.003, OR=0.045, 95% CI: 0.006–0.355). Conclusion: Our data reinforce the potential role of the IL-23 as a critical regulatory molecule that bridges the innate and adaptive arms of the immune system in the complex mechanisms associated with the development of atherosclerosis.