Polymorphisms of Glutathione S-Transferase Mu 1 (GSTM1), Theta 1 (GSTT1), and Pi 1 (GSTP1) Genes and Epithelial Ovarian Cancer Risk. Issue 3 (21st May 2013)

• Record Type: Journal Article
• Authors: Oliveira, Cristiane; Lourenço, Gustavo Jacob; Sagarra, Regina Aparecida Martinho; Derchain, Sophie Françoise Mauricette; Segalla, José Getulio; Lima, Carmen Silvia Passos
• Is Part Of: Disease markers. Volume 33:Issue 3(2012)
• Page Start: 155
• Page End: 159
• Publication Date: 2013-05-21
• Subjects: Epithelial ovarian cancer -- risk -- GSTM1 -- GSTT1 -- GSTP1; Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.3233/DMA-2012-0920
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : Background : Exposure of ovarian cells to estrogen, which is detoxified by glutathione S-transferases (GSTs), has been associated with epithelial ovarian cancer (EOC) development. Objectives : We tested in this study whether the GSTM1, GSTT1 and GSTP1 Ile105Val polymorphisms alter the risk of EOC. Materials and methods : Genomic DNA from 132 EOC patients and 132 controls was analyzed by polymerase chain reaction and restriction fragment length polymorphism methods. The differences between groups were analyzed by χ 2 or Fisher's exact test. Results : The frequencies of GSTP1 Ile/Ile (57.6% versus 45.5%, P = 0.03), GSTM1 null plus GSTP1 Ile/Ile (43.5% versus 25.8%; P = 0.03) and GSTM1 null plus GSTT1 null plus GSTP1 Ile/Ile (30.3% versus 7.7%; P = 0.007) genotypes were higher in patients than in controls. Individuals with the respective genotypes had a 1.80 (95% CI: 1.06–3.06), 2.38 (95% CI: 1.08–5.24) and 11.28 (95%CI: 1.95–65.30)-fold increased risks of EOC than those with the remaining genotypes. Conclusions : Our data present preliminary evidence that GSTM1, GSTT1 and GSTP1 polymorphisms, particularly in combination, constitute important inherited EOC determinants in individuals from Southeastern Brazil.