Cord Blood Levels of IL-6, IL-8 and IL-10 May Be Early Predictors of Bronchopulmonary Dysplasia in Preterm Newborns Small for Gestational Age. Issue 1 (23rd May 2013)

• Record Type: Journal Article
• Authors: Rocha, Gustavo; Proença, Elisa; Guedes, Ana; Carvalho, Carmen; Areias, Augusta; Ramos, João Pedro; Rodrigues, Teresa; Guimarães, Hercília
• Is Part Of: Disease markers. Volume 33:Issue 1(2012)
• Page Start: 51
• Page End: 60
• Publication Date: 2013-05-23
• Subjects: Bronchopulmonary dysplasia -- cytokines -- inflammation -- small for gestational age -- preterm newborn; Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.3233/DMA-2012-0903
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : Introduction : Various cytokines have been associated to the occurrence of bronchopulmonary dysplasia (BPD) in preterm neonates. AIM : To establish an association between cord blood cytokines and BPD, so that they could be used, in clinical practice, as early markers of BPD. Material and methods : Preterms less than 30 weeks gestational age, were analysed by ELISA microassay for venous cord blood IL-1 β, IL-6, IL-8, TNF- α and IL-10, and compared between the BPD and non-BPD groups. Results : One hundred and fifty neonates completed the study; 31 (21%) small for gestational age (SGA); 16 were deceased before 28 days of life; 36 developed mild BPD and 20 developed moderate/severe BPD. Elevated cord blood IL-8 was associated with death or moderate/severe BPD. SGA patients with moderate/severe BPD presented higher cord blood values of IL-8, lower IL-6 and IL-10 when compared with SGA without moderate/severe BPD; and higher IL-8 levels when compared with patients without moderate/severe BPD. Conclusion : These results support an association between cord blood IL-8 and moderate/severe BPD, independently of the intra-uterine growth; and the association of cord blood IL-6 and IL-10 and moderate/severe BPD in SGA preterm newborns.