Increased Salivary Levels of 8-Hydroxydeoxyguanosine May Be a Marker for Disease Activity for Periodontitis. Issue 3 (26th May 2013)

• Record Type: Journal Article
• Authors: Sezer, Ufuk; Çiçek, Yasin; Çanakçi, Cenk Fatih
• Is Part Of: Disease markers. Volume 32:Issue 3(2012)
• Page Start: 165
• Page End: 172
• Publication Date: 2013-05-26
• Subjects: Periodontitis -- saliva -- 8-hydroxydeoxyguanosine -- clinical attachment level -- disease activity -- oxidative DNA damage; Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.3233/DMA-2011-0876
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : Background : 8-hydroxydeoxyguanosine (8-OHdG) is commonly used as a marker to evaluate oxidative DNA damage in disorders including chronic inflammatory diseases such as inflammatory periodontal pathologies. In the current study we hypothesized that the level of 8-OHdG in saliva increases by the periodontal destruction severity determined by clinical parameters as clinical attachment level (CAL). Materials and methods : A cross-sectional study was conducted on a sum of 60 age gender balanced; chronic periodontitis (CP) ( n = 20), chronic gingivitis (CG) ( n = 20) and healthy (H) ( n = 20) individuals. Clinical periodontal parameters and salivary 8-OHdG levels were evaluated. Results : The mean 8-OHdG level in the saliva of the CP group was significantly higher than H and CG groups ( p < 0.001). Statistically significant correlation was only observed between the salivary levels of 8-OHdG and age ( p < 0.05), probing depth (PD) and CAL ( p < 0.001) in CP group. However, when CP patients were classified according to their CAL levels (CAL≥ 3 mm ( n = 11) and CAL<3 mm ( n = 9)) statistically significant correlation was only observed between the salivary levels of 8-OHdG and CAL≥ 3 mm patients ( p < 0.001). Conclusion : We suggest that elevated salivary levels of 8-OHdG may be a marker for disease activity and it may reflect indirectly disease severity parameters such as CAL.