A Systems Approach to the Proteomic Identification of Novel Cancer Biomarkers. Issue 4 (30th May 2013)

• Record Type: Journal Article
• Authors: Pitteri, Sharon; Hanash, Sam
• Is Part Of: Disease markers. Volume 28:Issue 4(2010)
• Page Start: 233
• Page End: 239
• Publication Date: 2013-05-30
• Subjects: Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.3233/DMA-2010-0696
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : The proteomics field has experienced rapid growth with technologies achieving ever increasing accuracy, sensitivity, and throughput, and with availability of computational tools to address particular applications. Given that the proteome represents the most functional component encoded for in the genome, a systems approach to disease investigations and biomarker identification benefits substantially from integration of proteome level studies. Here we present proteomic approaches that have allowed systematic searches for potential cancer markers by integrating cancer cell profiling with additional sources of data, as illustrated with recent studies of ovarian cancer.