Inflammatory epilepsy (FIRES) and haemophagocytic lymphohistiocytosis (HLH): an adult case. Issue 1 (31st January 2023)

• Record Type: Journal Article
• Authors: Kam, Ian; Prentice, David; Kho, Lay Kun; Dharsono, Ferry
• Is Part Of: BMJ case reports. Volume 16:Issue 1(2023)
• Publication Date: 2023-01-31
• Subjects: Epilepsy and seizures -- Immunology; Medicine -- Case studies -- Periodicals; 610.5
• DOI: 10.1136/bcr-2022-252637
• Languages: English
• ISSNs: 1757-790X

Abstract

Abstract : We describe a man in his 30s with haemophagocytic lymphohistiocytosis (HLH), secondary to an upper respiratory tract infection, with subsequent febrile infection-related epilepsy syndrome. He had a prolonged hospital admission, during which he was treated with chemotherapy for HLH and antiepileptic medications for refractory seizures. He was discharged fully dependent to a care facility and died from aspiration pneumonia 11 months later. This case report highlights his management and discusses these conditions' pathophysiology and future management.