Obesity and metabolic dysfunction correlate with background parenchymal enhancement in premenopausal women. Issue 2 (11th January 2023)

• Record Type: Journal Article
• Authors: Brown, Justin C.; Ligibel, Jennifer A.; Crane, Tracy E.; Kontos, Despina; Yang, Shengping; Conant, Emily F.; Mack, Julie A.; Ahima, Rexford S.; Schmitz, Kathryn H.
• Is Part Of: Obesity. Volume 31:Issue 2(2023)
• Page Start: 479
• Page End: 486
• Publication Date: 2023-01-11
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.23649
• Languages: English
• ISSNs: 1930-7381

Abstract

Abstract: Objective: This study tested the hypothesis that obesity and metabolic abnormalities correlate with background parenchymal enhancement (BPE), the volume and intensity of enhancing fibroglandular breast tissue on dynamic contrast‐enhanced magnetic resonance imaging. Methods: Participants included 59 premenopausal women at high risk of breast cancer. Obesity was defined as BMI ≥ 30 kg/m 2 . Metabolic parameters included dual‐energy x‐ray absorptiometry‐quantified body composition, plasma biomarkers of insulin resistance, adipokines, inflammation, lipids, and urinary sex hormones. BPE was assessed using computerized algorithms on dynamic contrast‐enhanced magnetic resonance imaging. Results: BMI was positively correlated with BPE ( r = 0.69; p < 0.001); participants with obesity had higher BPE than those without obesity (404.9 ± 189.6 vs. 261.8 ± 143.8 cm 2 ; Δ: 143.1 cm 2 [95% CI: 49.5‐236.7]; p = 0.003). Total body fat mass ( r = 0.68; p < 0.001), body fat percentage ( r = 0.64; p < 0.001), visceral adipose tissue area ( r = 0.65; p < 0.001), subcutaneous adipose tissue area ( r = 0.60; p < 0.001), insulin ( r = 0.59; p < 0.001), glucose ( r = 0.35; p = 0.011), homeostatic model of insulin resistance ( r = 0.62; p < 0.001), and leptin ( r = 0.60; p < 0.001) were positively correlated with BPE. Adiponectin ( r = −0.44; p < 0.001) was negatively correlated with BPE. Plasma biomarkers of inflammation and lipids and urinary sex hormones were not correlated with BPE. Conclusions: In premenopausal women at high risk of breast cancer, increased BPE is associated with obesity, insulin resistance, leptin, and adiponectin.