Physical activity, physical fitness and cardiometabolic risk amongst adults with moderate and severe haemophilia. Issue 1 (4th October 2022)

• Record Type: Journal Article
• Authors: Kennedy, Megan; Roche, Sheila; McGowan, Mark; Singleton, Evelyn; Elsheikh, Einas; O'Donovan, Mairead; Ryan, Kevin; O'Connell, Niamh M.; O'Mahony, Brian; Lavin, Michelle; O'Donnell, James S.; Turecek, Peter L.; Gormley, John
• Is Part Of: Haemophilia. Volume 29:Issue 1(2023)
• Page Start: 72
• Page End: 83
• Publication Date: 2022-10-04
• Subjects: cardiometabolic risk -- fitness -- haemophilia -- hypertension -- obesity -- physical activity; Hemophilia -- Periodicals; 616.1572005
• DOI: 10.1111/hae.14653
• Languages: English
• ISSNs: 1351-8216

Abstract

Abstract: Aim: This study aimed to examine physical activity (PA), physical fitness and cardiometabolic risk amongst people with moderate and severe haemophilia (PwMSH). Methods: The following domains were examined: PA (accelerometry); functional aerobic capacity (6‐Minute Walk Test); grip strength (dynamometry); balance (One Leg Stand Test); body composition (anthropometry and bioimpedance analysis); blood pressure; arterial stiffness; and cardiometabolic disorders. Results: A total of 53 PwMSH (44 years) and 33 controls (43 years; p = .679) were recruited. Compared to controls, PwMSH were significantly less active in moderate and vigorous PA parameters (all p < .05), and less physically fit indicated by 6‐Minute Walk distance ( p < .0005), grip strength ( p = .040) and balance ( p < .0005). PwMSH had higher rates of abdominal adiposity compared to controls measured by waist circumference indices (all p < .05). Resting blood pressure and arterial stiffness were not significantly different ( p = .797 and .818, respectively). With respect to overall PA, World Health Organisation recommended targets for adults were achieved by the majority of both groups (haemophilia: 72.9% vs. controls: 90.0%; p = .069). Importantly, the number of PwMSH who achieved guideline recommended PA via longer, sustained bouts of moderate–vigorous PA was significantly lower compared to controls (18.8% vs. 56.7%; p = .001). Lastly, clinically diagnosed hypertension, insulin resistance and hyperlipidaemia were more prevalent amongst PwMSH compared to controls. Conclusion: Low levels of PA and physical fitness, and significant rates of abdominal adiposity and hypertension may collectively influence the risk and severity of various cardiometabolic and/or musculoskeletal health issues amongst ageing PwMSH. Personalised multi‐disciplinary health interventions involving PA, dietary and health psychology input for PwMSH warrant future investigation.