Modulated Ultrasmall γ‐Fe2O3 Nanocrystal Assemblies for Switchable Magnetic Resonance Imaging and Photothermal‐Ferroptotic‐Chemical Synergistic Cancer Therapy. (20th November 2022)

• Record Type: Journal Article
• Authors: Yang, Baochan; Zhang, Yiming; Sun, Lixin; Wang, Jian; Zhao, Zunling; Huang, Zhuoyue; Mao, Wei; Xue, Rong; Chen, Runsheng; Luo, Jianjun; Wang, Tianyu; Jiang, Jianzhuang; Qin, Yan
• Is Part Of: Advanced functional materials. Volume 33:Number 5(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-11-20
• Subjects: ferroptosis -- hierarchical Fe 2O 3 architectures -- highly efficient second near‐infrared photothermal conversion -- photothermal‐ferroptotic‐chemical synergistic cancer therapy -- switchable magnetic resonance imaging; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.202211251
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract: Ferroptosis is recently discovered programmed cell death, induced by cellular ferrous ion bursts and subsequent Fenton reactions. The iron source in tumor cells is limited due to tightly controlled iron metabolism. Since hierarchical iron architecture is rarely considered in ferroptosis cancer treatment, multilayer Fe2 O3 architectures (UF@PPDF NPs) are developed by modulating ultra‐small γ‐Fe2 O3 nanocrystal assemblies, and further conjugating cancer cell targeting folic acid (FA), chemotherapeutic drug doxorubicin (Dox). Hierarchically assembled γ‐Fe2 O3 nanocrystal facilitates switchable magnetic resonance imaging (MRI), much enhanced ferroptosis efficiency, and very high second near‐infrared (NIR‐II) photothermal conversion. For MRI, UF@PPDF nanoparticles (NPs) enables clearly visualized tissues in terms of size and compactness, with dynamic T2‐T1 imaging switching. UF@PPDF NPs exhibits highly efficient photothermal therapy (PTT) upon NIR‐II irradiation, together with controlled release of ferric ions and Dox, thus achieving PTT‐chemotherapy‐ferroptosis trifunctional synergistic cancer therapy for tumor ablation. RNA sequencing analyses of differentially expressed genes implies a multifaceted role for this therapy in cancer cell signaling. Cellular respiration and electron transport are significantly upregulated, while the epigenetic pathways, including chromatin modification and RNA transcription activity are severely downregulated, with an overall effect of cellular apoptosis. Thus, γ‐Fe2 O3 architectures provide new possibility for highly efficient deep tumor treatment. Abstract : Modulating hierarchical architectures produces ultrasmall Fe2 O3 nanocrystal assembles conjugated with cancer cell targeting folic acid and chemotherapeutic drug doxorubicin. Dependent on the assembled Fe2 O3 nanocrystals, these architectures show dynamically switchable magnetic resonance imaging, and highly efficient photothermal‐ferroptotic‐chemical synergistic cancer therapy for tumor ablation. RNA sequencing analyses suggest ferroptosis is fundamental during synergistic therapy, despite excellent second near‐infrared photothermal conversion.