Cell‐Based Drug Delivery Systems Participate in the Cancer Immunity Cycle for Improved Cancer Immunotherapy. Issue 4 (27th November 2022)

• Record Type: Journal Article
• Authors: Fan, Xiaoyuan; Wang, Kaiyuan; Lu, Qi; Lu, Yutong; Sun, Jin
• Is Part Of: Small. Volume 19:Issue 4(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-11-27
• Subjects: cancer immunity cycles -- cancer immunotherapy -- cancer vaccines -- cell‐based delivery systems -- tumor targeting; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.202205166
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract: Immunotherapy aims to activate the cancer patient's immune system for cancer therapy. The whole process of the immune system against cancer referred to as the "cancer immunity cycle", gives insight into how drugs can be designed to affect every step of the anticancer immune response. Cancer immunotherapy such as immune checkpoint inhibitor (ICI) therapy, cancer vaccines, as well as small molecule modulators has been applied to fight various cancers. However, the effect of immunotherapy in clinical applications is still unsatisfactory due to the limited response rate and immune‐related adverse events. Mounting evidence suggests that cell‐based drug delivery systems (DDSs) with low immunogenicity, superior targeting, and prolonged circulation have great potential to improve the efficacy of cancer immunotherapy. Therefore, with the rapid development of cell‐based DDSs, understanding their important roles in various stages of the cancer immunity cycle guides the better design of cell‐based cancer immunotherapy. Herein, an overview of how cell‐based DDSs participate in cancer immunotherapy at various stages is presented and an outlook on possible challenges of clinical translation and application in future development. Abstract : In this review, various types of cells in cell‐based drug delivery systems (DDSs) are summarized. In addition, how cell‐based DDSs participate in every stage of the cancer immunity cycle through various strategies, such as cell membrane wrapping, cell conjugation, cell encapsulation and cell surface modification, are outlined. Finally, the outlooks and potential challenges of cell‐based DDSs in cancer immunotherapy are highlighted.