Vacancy‐Modulated of CuS for Highly Antibacterial Efficiency via Photothermal/Photodynamic Synergetic Therapy. Issue 1 (6th November 2022)

• Record Type: Journal Article
• Authors: Zhang, Zhihao; Wen, Jinghong; Zhang, Jie; Guo, Donggang; Zhang, Quanxi
• Is Part Of: Advanced healthcare materials. Volume 12:Issue 1(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-11-06
• Subjects: antibacterial efficiency -- CuS nanospheres -- photodynamic therapy -- photothermal therapy -- vacancy engineering; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202201746
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: Cu‐based nanomaterials have been developed to alleviate the problem of antibiotic resistance due to their superior properties and good biocompatibility. Defects in nanomaterials have a major role in improving photocatalytic performance. Herein, two CuS nanospheres with predominant V CuSCu and V CuSS vacancy (abbreviated as CuS and CuS‐T150, respectively) characterized by positron annihilation spectra are synthesized. The combination of experimental and theoretical calculation results demonstrates that CuS‐T150 exhibits excellent antibacterial, achieving bactericidal rates of 99.9% against to Escherichia coli ( E. coli ) under 808 nm laser irradiation. Compared with CuS, the superior antimicrobial activity of CuS‐T150 is mainly attributed to its stronger ability to adsorb oxygen molecules, more easily bind with surface of E. coli, and higher photothermal conversion efficiency (PTCE). This work provides a deeper understanding of nanomaterials with vacancy modulated the antibacterial efficiency by synergistic effect of photodynamic and photothermal therapy. Abstract : In this work, two CuS samples with different types of vacancies (CuS with V CuSCu and CuS‐T150 with V CuSS ) are prepared by a simple hydrothermal synthesis method. Compared with CuS, the superior antimicrobial activity of CuS‐T150 is mainly attributed to its stronger ability to adsorb oxygen molecules, more easily bind with surface of E. coli, and higher photothermal conversion efficiency (PTCE).