Inside Cover: Darobactins Exhibiting Superior Antibiotic Activity by Cryo‐EM Structure Guided Biosynthetic Engineering (Angew. Chem. Int. Ed. 2/2023). Issue 2 (14th December 2022)

• Record Type: Journal Article
• Authors: Seyfert, Carsten E.; Porten, Christoph; Yuan, Biao; Deckarm, Selina; Panter, Fabian; Bader, Chantal D.; Coetzee, Janetta; Deschner, Felix; Tehrani, Kamaleddin H. M. E.; Higgins, Paul G.; Seifert, Harald; Marlovits, Thomas C.; Herrmann, Jennifer; Müller, Rolf
• Is Part Of: Angewandte Chemie international edition. Volume 62:Issue 2(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-12-14
• Subjects: Antibiotics -- BamA -- CRAB -- Cryo-Electron Microscopy -- Natural Products; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.202217800
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract : Darobactins bind to the novel antibiotic target BamA in the outer membrane BAM‐complex of Gram‐negative pathogens. The renewal of the outer membrane proteins is prevented and bacteria are lysed. The new derivative D22 was created through cryo‐EM structure‐ and activity‐guided biosynthetic engineering as described by Thomas C. Marlovits, Jennifer Herrmann, Rolf Müller, and co‐workers in their Research Article (e202214094), and showed superior potency against multidrug‐resistant clinical isolates, for which most antibiotics on the market are no longer effective.