Effects of occupational exposure to trace levels of halogenated anesthetics on the liver, kidney, and oxidative stress parameters in operating room personnel. (2nd July 2020)

• Record Type: Journal Article
• Authors: Jafari, Abbas; Jafari, Fatemeh; Mohebbi, Iraj
• Is Part Of: Toxin reviews. Volume 39:Number 3(2020)
• Page Start: 242
• Page End: 251
• Publication Date: 2020-07-02
• Subjects: Operating room -- anesthetic gases -- oxidative stress -- liver toxicity; Toxicology -- Periodicals; Toxins -- Periodicals; 615.905
• DOI: 10.1080/15569543.2018.1498898
• Languages: English
• ISSNs: 1556-9543

Abstract

Abstract: This study was conducted to measure the concentration of halogenated anesthetics in breathing zone air of the personnel and evaluate their effects on hepatic and renal functions as well as oxidative stress parameters. Levels of these gases in air samples were lower than the national recommended exposure limits (50 ppm). Occupational exposure to anesthetic gases significantly induced oxidative stress in the operating room personnel, marked by increased plasma levels of transaminase enzymes accompanied by the marked decline of enzymatic and non-enzymatic antioxidant levels, and the rise of MDA levels ( p < 0.05); these adverse effects would increase with increasing work experience.