The effect of captopril on inflammation-induced liver injury in male rats. (2nd July 2020)

• Record Type: Journal Article
• Authors: Azizi-Malekabadi, Hamid; Abareshi, Azam; Beheshti, Farimah; Marefati, Narges; Norouzi, Fatemeh; Soukhtanloo, Mohammad; Hosseini, Mahmoud
• Is Part Of: Toxin reviews. Volume 39:Number 3(2020)
• Page Start: 275
• Page End: 283
• Publication Date: 2020-07-02
• Subjects: Lipopolysaccharide -- liver -- captopril -- oxidative stress -- inflammation; Toxicology -- Periodicals; Toxins -- Periodicals; 615.905
• DOI: 10.1080/15569543.2018.1517802
• Languages: English
• ISSNs: 1556-9543

Abstract

Abstract: Activation of macrophages-induced by lipopolysaccharide (LPS) is accompanied by the production of reactive oxygen species and inflammatory cytokines to induce hepatic injury. Renin–angiotensin system may play a role in liver damage. In the current study, the effect of captopril on the injury of inflammation-induced liver was investigated. The rats were divided into (1) Control, (2) LPS, and (3–5) LPS as well as 10, 50, or 100 mg/kg captopril for 2 weeks. Captopril decreased NO metabolites, IL-6, and MDA, while it increased CAT, SOD, and total thiol in the liver. Captopril also attenuated AST, ALT, and ALK-P, whereas it increased albumin and total protein in serum. As an ACE inhibitor, captopril improved liver function and attenuated inflammation and oxidative stress induced by LPS injection.