Mean serum D-dimer level to predict in-hospital mortality in Covid-19 patients. (14th October 2021)

• Record Type: Journal Article
• Authors: Hayiroglu, M I; Cicek, V; Kilic, S; Cinar, T
• Is Part Of: European heart journal. Volume 42(2021)Supplement 1
• Publication Date: 2021-10-14
• Subjects: Cardiac Care Unit (CCU), Intensive, and Critical Cardiovascular Care; Cardiology -- Periodicals; Heart -- Diseases -- Periodicals; 616.12005
• DOI: 10.1093/eurheartj/ehab724.1514
• Languages: English
• ISSNs: 0195-668X

Abstract

Abstract: Background: The prognostic effect of the mean serum D-dimer levels, which was calculated from the first five hospitalization days of the patients, have not been elucidated. We aim to evaluate the effect of mean D-dimer level in regard to in-hospital mortality in patients hospitalized due to COVID-19 infection. Material and methods: In this observational retrospective study, we examined the in-hospital prognostic value of mean D-dimer (D-dimer first day + D-dimer third day + D-dimer fifth day) / 3 on 240 consecutive adult patients with COVID-19. Patients were stratified into tertiles according to their mean D-dimer starting from the lowest one. In-hospital mortality rates were compared between tertiles and the power of the mean D-dimer level was also presented by a receiver operating curve (ROC) analysis. Results: After adjustment for confounding baseline variables, mean D-dimer in tertile 3 was associated with an 4.2-fold hazard ratio of in-hospital mortality (OR: 4.2, 95% CI 1.8–20.1, p<0.001). A ROC analysis revealed that the optimal cut-off value of the mean D-dimer to predict in-hospital mortality was 779 μg/L with 77% sensitivity and 83% specificity (AUC: 0.87; 95% CI: 0.81–0.94; p<0.001). Conclusion: Patients with a higher mean D-dimer level should be followed-up more closely since they may be a candidate for a more aggressive treatment modality, such as biologic agents or convalescent plasma. FUNDunding Acknowledgement: Type of funding sources: None.