Bifenazate exposure induces cardiotoxicity in zebrafish embryos. (1st April 2021)

• Record Type: Journal Article
• Authors: Ma, Jinze; Huang, Yong; Peng, Yuyang; Xu, Zhaopeng; Wang, Ziqin; Chen, Xiaobei; Xie, Shuling; Jiang, Ping; Zhong, Keyuan; Lu, Huiqiang
• Is Part Of: Environmental pollution. Volume 274(2021)
• Publication Date: 2021-04-01
• Subjects: Bifenazate -- Cardiotoxicity -- Oxidative stress -- Heart failure -- Calcium signaling pathway; Pollution -- Periodicals; Pollution -- Environmental aspects -- Periodicals; Environmental Pollution -- Periodicals; Pollution -- Périodiques; Pollution -- Aspect de l'environnement -- Périodiques; Pollution -- Effets physiologiques -- Périodiques; Pollution; Pollution -- Environmental aspects; Periodicals; Electronic journals; 363.73
• DOI: 10.1016/j.envpol.2021.116539
• Languages: English
• ISSNs: 0269-7491

Abstract

Abstract: Bifenazate is a novel acaricide for selective foliar spraying and is widely used to control mites in agricultural production. However, its toxicity to aquatic organisms is unknown. Here, a zebrafish model was used to study bifenazate toxicity to aquatic organisms. Exposure to bifenazate was found to cause severe cardiotoxicity in zebrafish embryos, along with disorders in the gene expression related to heart development. Bifenazate also caused oxidative stress. Cardiotoxicity caused by bifenazate was partially rescued by astaxanthin (an antioxidant), accompanied by cardiac genes and oxidative stress-related indicators becoming normalized. Our results showed that exposure to bifenazate can significantly change the ATPase activity and gene expression levels of the calcium signaling pathway. These led to heart failure, in which the blood accumulated outside the heart without entering it, eventually leading to death. The results indicated that bifenazate exposure caused cardiotoxicity in zebrafish embryos through the induction of oxidative stress and inhibition of the calcium signaling pathway. Graphical abstract: Image 1 Highlights: Bifenazate induces cardiac development toxicity in zebrafish embryos. Bifenazate causes oxidative stress in zebrafish embryos. Bifenazate induces cell apoptosis in zebrafish heart. Bifenazate significantly downregulates ATPase activity, which leads to insufficient blood supply to the heart .