Expression of Hypoxia-Inducible Factor (HIF)-1α and Vascular Endothelial Growth Factor (VEGF)-D As Outcome Predictors in Resected Esophageal Squamous Cell Carcinoma. Issue 3 (4th June 2013)

• Record Type: Journal Article
• Authors: Tzao, Ching; Lee, Shih-Chun; Tung, Ho-Jui; Hsu, Han-Shui; Hsu, Wen-Hu; Sun, Guang-Huan; Yu, Cheng-Ping; Jin, Jong-Shiaw; Cheng, Yeung-Leung
• Is Part Of: Disease markers. Volume 25:Issue 3(2008)
• Page Start: 141
• Page End: 148
• Publication Date: 2013-06-04
• Subjects: vascular endothelial growth factor (VEGF)-D -- esophageal squamous cell carcinoma -- prognosis -- survival; Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.1155/2008/468323
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : Hypoxia-inducible factor (HIF)-1 α and vascular endothelial growth factor (VEGF) are important angiogenic factors in human cancers. Relative to VEGF-C, prognostic significance of VEGF-D expression and its association with HIF-1 α expression remain elusive in esophageal squamous cell cancer (ESCC). We studied expression of HIF-1 α and VEGF-D using immunohistochemistry in 85 resected ESCC specimens and correlated results with patients' clinicopathologic parameters and survival. Association between expression of HIF-1 α and VEGF-D was investigated using a concordance analysis. High expression of HIF-1 α and VEGF-D was observed in 52 (61.2%) and 56 (65.9%) patients, respectively. HIF-1 α expression correlated well with tumor stage ( P = 0.041), whereas VEGF-D expression correlated with tumor stage ( P = 0.027) and N status ( P = 0.019). Groups of high HIF-1 α and VEGF-D showed worse survivals than those of low expression ( P = 0.002 and 0.001, respectively). Multivariate analysis supported expression of HIF-1 α and VEGF-D as significant survival predictors ( P = 0.044 and 0.035, respectively). A concordance rate of 69.5% was observed between expression of HIF-1 α and VEGF-D. In conclusion, protein expression of HIF-1 α and VEGF-D are independent prognostic predictors. An association between expression of HIF-1 α and VEGF-D suggests that these two angiogenic factors are essential in progression of ESCC.