Chromosome 9p21.3 is Associated with Early-Onset Coronary Heart Disease in the Irish Population. Issue 2 (4th June 2013)

• Record Type: Journal Article
• Authors: Meng, Weihua; Hughes, Anne E.; Patterson, Chris C.; Belton, Christine; Kee, Frank; McKeown, Pascal P.
• Is Part Of: Disease markers. Volume 25:Issue 2(2008)
• Page Start: 81
• Page End: 85
• Publication Date: 2013-06-04
• Subjects: Coronary heart disease -- chromosome 9p21.3 -- genetics; Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.1155/2008/375617
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : Coronary heart disease (CHD) remains a leading cause of death across the world. A region on chromosome 9p21.3 has been recently reported to be associated with CHD. We evaluated 3 SNPs and 3 common haplotypes in the 9p21.3 region in 1494 individuals from 580 Irish families, where at least 1 member had early-onset (males ≤55yr, females ≤60yr) CHD. Genotypes were determined by multiplex SNaPshot technology. Using the combined TDT/S-TDT test, the 3 single nucleotide polymorphisms (SNP), rs10757274, rs2383206 and rs1333049, were strongly associated with early-onset CHD ( p = 2.7 × 10 -6, 2.7 × 10 -6, 3.8 × 10 -7, respectively). Analysis of haplotypes by the TRANSMIT program also showed that the GGC haplotype was associated with early-onset CHD ( p = 7.9 × 10 -7 ). In conclusion, using a family-based approach in the Irish population, we have confirmed previous reports of association between a region on chromosome 9p21.3 and early-onset CHD.