Mast Cells, TGF-β1 and α-SMA Expression in IgA Nephropathy. Issue 3 (2008)

• Record Type: Journal Article
• Authors: Silva, G. E. B.; Costa, R. S.; Ravinal, R. C.; dos Reis, M. A.; Dantas, M.; Coimbra, T. M.
• Is Part Of: Disease markers. Volume 24:Issue 3(2008)
• Page Start: 181
• Page End: 190
• Publication Date: 2008
• Subjects: Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.1155/2008/725408
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : IgA nephropathy (IgAN) is a kidney disease with a varying renal prognosis. Recently, many studies have demonstrated that renal α -smooth muscle actin ( α -SMA) and transforming growth factor (TGF- β 1) expression, as well interstitial mast cell infiltrates could represent a prognostic marker in several renal diseases. The aim of our study was to analyze the prognostic value of mast cell, TGF- β 1 and α -SMA expression in IgAN. A survey of the medical records and renal biopsy reports of 62 patients with a diagnosis of IgAN followed-up from 1987 to 2003 was performed. The mean follow-up time was 74.7 ± 50.0 months. The immunohistochemical studies were performed using a monoclonal antibody anti-human mast cell tryptase, a polyclonal antibody anti-human TGF- β 1, and a monoclonal antibody anti-human α -SMA. An unfavorable clinical course of IgAN was related to interstitial mast cell infiltrates and α -SMA expression in the tubulointerstitial area. Expression of glomerular TGF- β 1 and α -SMA, and interstitial TGF- β 1 is not correlated with clinical course in IgAN. In conclusion, the increased number of mast cells and higher α-SMA expression in the tubulointerstitial area may be predictive factors for the poor prognosis of patients with IgAN.