An Increase in N-Ras Expression is Associated with Development of Hormone Refractory Prostate Cancer in a Subset of Patients. Issue 3 (2008)

• Record Type: Journal Article
• Authors: Traynor, Pamela; McGlynn, Liane M.; Mukhergee, Rono; Grimsley, Samuel J. S.; Bartlett, John M. S.; Edwards, Joanne
• Is Part Of: Disease markers. Volume 24:Issue 3(2008)
• Page Start: 157
• Page End: 165
• Publication Date: 2008
• Subjects: Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.1155/2008/918087
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : Protein expression of H, K and N-Ras was assessed in hormone sensitive and hormone refractory prostate tumour pairs from 61 patients by immunohistochemistry. Expression of H-Ras and K- Ras was not associated with any known clinical parameters. In contrast an increase in N-Ras membrane expression in the transition from hormone sensitive to hormone refractory prostate cancer was associated with shorter time to relapse ( p = 0.01) and shorter disease specific survival ( p = 0.008). In addition, patients with an increase in N-Ras membrane expression had lower levels of PSA at relapse ( p = 0.02) and expression correlated with phosphorylated MAP kinase ( p = 0.010) and proliferation index (Ki67, p = 0.02). These results suggest that in a subgroup patients N-Ras expression is associated with development of hormone refractory prostate cancer via activation of the MAP kinase cascade.