Evidence for an Association between the SRD5A2 (Type II Steroid 5α-Reductase) Locus and Prostate Cancer in Italian Patients. Issue 3 (2000)

• Record Type: Journal Article
• Authors: Margiotti, K.; Sangiuolo, F.; De Luca, A.; Froio, F.; Pearce, C. L.; Ricci-Barbini, V.; Micali, F.; Bonafè, M.; Franceschi, C.; Dallapiccola, B.; Novelli, G.; Reichardt, J. K. V.
• Is Part Of: Disease markers. Volume 16:Issue 3/4(2000)
• Page Start: 147
• Page End: 150
• Publication Date: 2000
• Subjects: Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.1155/2000/683607
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : We have investigated the contributions of three polymorphic markers in the SRD5A2 gene to prostate cancer in a group of Italian patients. We have genotyped cases and controls for a polymorphic (TA)n dinucleotide repeat and two functional substitutions, A49T and V89L, substituting respectively alanine with threonine at codon 49, and valine to leucine at codon 89. We found a substantially increased but not significant risk associated with the 49T mutation and a reduction of risk for the V89L substitution. In conclusion, we report on preliminary evidence for both increased and decreased risk associated with separate markers at this locus.