Implication of HLA-DMA Alleles in Corsican IDDM. Issue 3 (17th June 2013)

• Record Type: Journal Article
• Authors: Cucchi-Mouillot, P.; Lai, S.; Carcassi, C.; Sorba, P.; Stuart-Simoni, M.; Amoros, J.-P.; Genetet, B.; Haras, D.; Contu, L.
• Is Part Of: Disease markers. Volume 14:Issue 3(1998)
• Page Start: 135
• Page End: 141
• Publication Date: 2013-06-17
• Subjects: diabetes -- HLA-DMA -- Corsica; Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.1155/1998/705857
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : The HLA-DM molecule catalyses the CLIP/antigen peptide exchange in the classical class II peptide-binding groove. As such, DM is an antigen presentation regulator and may be linked to autoimmune diseases. Using PCR derived methods, a relationship was revealed between DM gene polymorphism and IDDM, in a Corsican population. The DMA*0101 allele was observed to confer a significant predisposition to this autoimmune disease while the DMA*0102 allele protected significantly. Experiments examining polymorphism of the HLA-DRB1 gene established that these relationships are not a consequence of linkage disequilibrium with HLA-DRB1 alleles implicated in this pathology. The study of the DMA gene could therefore be an additional tool for early IDDM diagnosis in the Corsican population.