Age-Dependent Decrease in Serum Transforming Growth Factor (TGF)-Beta 1 in Healthy Japanese Individuals; Population Study of Serum TGF-Beta 1 Level in Japanese. Issue 2 (9th June 2013)

• Record Type: Journal Article
• Authors: Okamoto, Yoshihiro; Gotoh, Yoshimitsu; Uemura, Osamu; Tanaka, Soichi; Ando, Tsunesaburo; Nishida, Mikio
• Is Part Of: Disease markers. Volume 21:Issue 2(2005)
• Page Start: 71
• Page End: 74
• Publication Date: 2013-06-09
• Subjects: transforming growth factor (TGF)-β1 -- human -- serum; Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.1155/2005/381215
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : Transforming growth factor-beta1 (TGF- β 1), a multi-functional cytokine, is involved in regulating a variety of cellular activities and the serum/plasma TGF- β 1 level is altered with various diseases. However, most published reports have described adult patients, and so we investigated the clinical significance of serum TGF- β 1 level in pediatric patients. The diagnostic application of the measurement of serum TGF- β 1 level depends critically on the control value, however, there is no information on the control value of serum TGF- β 1 for children. In the present study, we determined the serum TGF- β 1 level of healthy Japanese children as a control value with enzyme-linked immunosorbent assay (ELISA). The serum TGF- β 1 level of children (0–14 years old) was significantly higher than that of adults (over 15 years old) ( p < 0.01). Thus, it is recommended that when the serum TGF-β1 levels of patients are evaluated, they should be compared with those of age-matched controls.