Tailoring Electrode Surface Charge to Achieve Discrimination and Quantification of Chemically Similar Small Molecules with Electrochemical Aptamers (Adv. Funct. Mater. 1/2023). (3rd January 2023)

• Record Type: Journal Article
• Authors: Kesler, Vladimir; Fu, Kaiyu; Chen, Yihang; Park, Chan Ho; Eisenstein, Michael; Murmann, Boris; Soh, H. Tom
• Is Part Of: Advanced functional materials. Volume 33:Number 1(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-01-03
• Subjects: cross‐reactivity -- drug discrimination -- drug quantification -- electrochemical aptamer biosensors -- nanostructured electrodes -- surface charge; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.202370001
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract : Electrochemical Aptamer Biosensors In article number 2208534, Fu, Soh, and co‐workers report an electrochemical biosensor to distinguish molecules with a minuscule difference in chemical composition by tuning the charge state of the surface on which the aptamer probes are immobilized. As an exemplar, it is shown that the strategy can distinguish between doxorubicin and many structurally similar analytes, including its primary metabolite, doxorubicin, which only differs by a single hydroxyl group.