Eph and ephrin signaling in the development of the central auditory system. Issue 1 (24th June 2022)

• Record Type: Journal Article
• Authors: Krasewicz, Jakub; Yu, Wei‐Ming
• Other Names: Deans Michael R. guestEditor.; Williams Megan E. guestEditor.; Kale Shubham guestEditor.
• Is Part Of: Developmental dynamics. Volume 252:Issue 1(2023)
• Page Start: 10
• Page End: 26
• Publication Date: 2022-06-24
• Subjects: auditory brainstem -- auditory cortex -- cochlear nucleus -- inferior colliculus -- superior olivary complex -- tonotopy; Morphogenesis -- Periodicals; Anatomy -- Periodicals; Anatomie -- Périodiques; Biologie du développement -- Périodiques; 571.833
• DOI: 10.1002/dvdy.506
• Languages: English
• ISSNs: 1058-8388

Abstract

Abstract: Acoustic communication relies crucially on accurate interpretation of information about the intensity, frequency, timing, and location of diverse sound stimuli in the environment. To meet this demand, neurons along different levels of the auditory system form precisely organized neural circuits. The assembly of these precise circuits requires tight regulation and coordination of multiple developmental processes. Several groups of axon guidance molecules have proven critical in controlling these processes. Among them, the family of Eph receptors and their ephrin ligands emerge as one group of key players. They mediate diverse functions at multiple levels of the auditory pathway, including axon guidance and targeting, topographic map formation, as well as cell migration and tissue pattern formation. Here, we review our current knowledge of how Eph and ephrin molecules regulate different processes in the development and maturation of central auditory circuits. Key Findings: Eph/ephrin signaling regulates the segregation and patterning of eighth cranial nerve central projections and tonotopic map precision of the CN. Eph/ephrin signaling regulates the assembly of the sound localization circuit in the auditory brainstem. Eph/ephrin signaling regulates the formation of tonotopic projections in the inferior colliculus. Eph/ephrin signaling regulates frequency tuning and axon targeting in the medial geniculate body and auditory cortex.