Female infertility in the era of obesity: The clash of two pandemics or inevitable consequence?. (7th June 2022)

• Record Type: Journal Article
• Authors: Medenica, Sanja; Spoltore, Maria Elena; Ormazabal, Paulina; Marina, Ljiljana V.; Sojat, Antoan Stefan; Faggiano, Antongiulio; Gnessi, Lucio; Mazzilli, Rossella; Watanabe, Mikiko
• Is Part Of: Clinical endocrinology. Volume 98:Number 2(2023)
• Page Start: 141
• Page End: 152
• Publication Date: 2022-06-07
• Subjects: assisted reproductive technology -- body mass index -- in vitro fertilization -- miscarriage -- overweight -- polycystic ovary syndrome -- pregnancy; Endocrinology -- Periodicals; 616.4005
• DOI: 10.1111/cen.14785
• Languages: English
• ISSNs: 0300-0664

Abstract

Abstract: Obesity is an epidemic that has led to a rise in the incidence of many comorbidities: among others, reduced fertility is often under‐evaluated in clinical practice. The mechanisms underlying the link between reduced fertility and obesity are numerous, with insulin resistance, hyperglycaemia and the frequent coexistence of polycystic ovary syndrome being the most acknowledged. However, several other factors concur, such as gut microbiome alterations, low‐grade chronic inflammation and oxidative stress. Not only do women with obesity take longer to conceive, but in vitro fertilization (IVF) is also less likely to succeed. We herein provide an updated state‐of‐the‐art regarding the molecular bases of what we could define as dysmetabolic infertility, focusing on the clinical aspects, as well as possible treatment.