Oxygen saturation targets in pediatric respiratory disease. Issue 1 (26th May 2022)

• Record Type: Journal Article
• Authors: Nagakura, Akito; Morikawa, Yoshihiko; Takasugi, Nao; Funakoshi, Hanako; Miura, Yoko; Ota, Tomomi; Shimizu, Ayumi; Shimizu, Keisuke; Shirane, Shoichiro; Hataya, Hiroshi
• Is Part Of: Pediatrics international. Volume 64:Issue 1(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-05-26
• Subjects: oxygen saturation target -- oxygen therapy -- respiratory disease; Pediatrics -- Periodicals; 618.92
• DOI: 10.1111/ped.15129
• Languages: English
• ISSNs: 1328-8067

Abstract

Abstract: Background: The present study aimed to assess the appropriate oxygen saturation target in patients with pediatric respiratory diseases by lowering the oxygen saturation target from SpO2 94% to 90%. No previous study has explored appropriate oxygen saturation targets in respiratory diseases other than bronchiolitis. Methods: The present, prospective, single‐arm intervention trial enrolled pediatric inpatients with bronchiolitis, bronchitis, pneumonia, and asthma. The oxygen saturation target was lowered from SpO2 94% to 90% after the patients' general condition improved. The patients continued to be observed for 12 h after achieving SpO2 94%. The duration from the first cut‐off point (SpO2 90% for 12 h without oxygen) to the second cut‐off point (SpO2 94% for 12 h) was then evaluated. Results: In total, 248 patients completed the study. Patients with bronchiolitis, bronchitis, pneumonia, and asthma had an interval between the two cut‐off points of 23.9, 15.5, 19.1, and 13.8 h, respectively, (mean 17.2 h; 95% confidence interval 15.0–19.5). Conclusions: In generally healthy children, setting the oxygen saturation target at SpO2 90% after confirming improvement in their general condition was safe. The time required for increasing SpO2 from 90% to 94% was longest in the patients with bronchiolitis.