Antioxidant and cytotoxic properties of some new dipeptide‐indole conjugates. (4th September 2022)

• Record Type: Journal Article
• Authors: Gönül, Zeynep; Öztürk, Dilara Altay; Küçükbay, Fatümetüzzehra; Tekin, Suat; Tekin, Zehra; Küçükbay, Hasan
• Is Part Of: Journal of heterocyclic chemistry. Volume 60:Number 1(2023)
• Page Start: 86
• Page End: 95
• Publication Date: 2022-09-04
• Subjects: Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.4564
• Languages: English
• ISSNs: 0022-152X

Abstract

Abstract: In this study, 10 new indole‐dipeptide conjugates were synthesized, and their anticancer activity was determined against on A2780 (ovarian cancer cell line) and MCF‐7 (breast cancer cell line) cells. Among compounds, 5 and 10 showed better activity against A2780 cell lines than the standard drug docatexel at 0.1 and 1 μM concentrations, while only compound 5 showed better activity than docatexel, the MCF‐7 cell line at 0.1 and 1 μM concentrations. The antioxidant potencies of the compounds were low in both the DPPH and iron reducing power methods tested when compared to standard antioxidants used in this work. Abstract : Dipeptide‐indole conjugates with cytotoxic avtivity.