Asperpyrone, a rare α-pyrone metabolite produced by an endophytic fungus Aspergillus sp. isolated from Garicinia smeathmannii (Planch. & Triana) Oliv. Issue 1 (2nd January 2023)

• Record Type: Journal Article
• Authors: Jouda, Jean-Bosco; Njoya, Emmanuel Mfotie; Nguengang, Ruland Tchuinkeu; Tankeu, Virginie Flaure Tsague; Stammler, Hans-Georg; Shiono, Yoshihito; Sewald, Norbert; Lannang, Alain Meli
• Is Part Of: Natural product research. Volume 37:Issue 1(2023)
• Page Start: 8
• Page End: 15
• Publication Date: 2023-01-02
• Subjects: Garicinia smeathmannii -- Aspergillus -- α-pyrone -- amoebicidal activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.1944139
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new α -pyrone, asperpyrone (1 ) and two known compounds, stigmasterol (2 ) and 7-hydroxy-3-(2, 3-dihydroxybutyl)-1(3 H )-Isobenzofuranone (3 ) were isolated from the solid rice culture of the endophytic fungus Aspergillus sp., an endophytic fungus isolated from the fresh inner tissue of the barks of Garicinia smeathmannii . Their structures were determined by extensive spectral analysis including 1 D and 2 D NMR, HRESIMS and single-crystal X-ray crystallographic analysis. Asperpyrone (1 ) was tested against an axenic culture of Entamoeba moshkovskii, but did not exhibit any significant amoebicidal activity. Graphical abstract: UF0001