Fingerprinting of two an acylated polyoxypregnane glycosides from Caralluma quadrangula (Forssk.) N.E.Br. using UPLC-ESI-Q-TOF and computational study. Issue 1 (2nd January 2023)

• Record Type: Journal Article
• Authors: Ben Said, Ridha; Ben Aissa, Mohamed Ali; Rahali, Seyfeddine; Tangour, Bahoueddine; Kowalczyk, Mariusz; Oleszek, Wieslaw; Stochmal, Anna; Hamed, Arafa I.
• Is Part Of: Natural product research. Volume 37:Issue 1(2023)
• Page Start: 136
• Page End: 140
• Publication Date: 2023-01-02
• Subjects: Caramulla quadrangula -- acylated polyoxypregnane glycosides -- UPLC-ESI-Q-TOF -- DFT; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.1948847
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: The present study has tentatively elucidated the structure of two acylated polyoxypregnane glycosides from Caralluma quadrangula (Forssk.) N.E.Br. ( CQ ). The analyses were performed using an electrospray-ionization quadrupole time-of-flight (ESI-Q-TOF) mass spectrometer in positive ionization modes to explore fragmentation pathways. The used ionization mode provided consistent and/or complementary information for most of the pregnane glycosides, their fragmentation sequences, and their aglycones. Presumably, this is due to higher efficiency, sensitivity, and better selectivity of the mass spectrometry-based method. The present experimental and theoretical report deals with the characteristic fragmentation behaviors of two acylated polyoxypregnane glycosides CQ1 and CQ2 from the aerial parts of C. quadrangular. A DFT Study was performed to elucidate the position of ikemoyl, and benzoyl residues in compounds CQ1 and CQ2, respectively. Graphical Abstract: UF0001