Peptide therapeutics: current status and future directions. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Fosgerau, Keld; Hoffmann, Torsten
• Is Part Of: Drug discovery today. Volume 20:Issue 1(2015)
• Page Start: 122
• Page End: 128
• Publication Date: 2015-01
• Subjects: Drugs -- Design -- Periodicals; Drugs -- Research -- Periodicals; 615.1
• DOI: 10.1016/j.drudis.2014.10.003
• Languages: English
• ISSNs: 1359-6446

Abstract

Highlights: We provide a SWOT analysis of peptide therapeutics and discuss commercial aspects. We comment on emerging peptide technologies and cell-penetrating peptides. Multifunctional peptides and peptide drug conjugates are discussed. We foresee intelligent design and assembly of peptide modules as molecular medicines. Peptides offer enormous growth potential as future therapeutics. Abstract : Peptides are recognized for being highly selective and efficacious and, at the same time, relatively safe and well tolerated. Consequently, there is an increased interest in peptides in pharmaceutical research and development (R&D), and approximately 140 peptide therapeutics are currently being evaluated in clinical trials. Given that the low-hanging fruits in the form of obvious peptide targets have already been picked, it has now become necessary to explore new routes beyond traditional peptide design. Examples of such approaches are multifunctional and cell penetrating peptides, as well as peptide drug conjugates. Here, we discuss the current status, strengths, and weaknesses of peptides as medicines and the emerging new opportunities in peptide drug design and development.