Generalised autonomic failure as a prognostic factor in systemic light-chain (AL) amyloidosis. (2nd October 2022)

• Record Type: Journal Article
• Authors: Kwon, Soonwook; Jeong, Woo Kyo; Park, Ji-Hyung; Kim, Juhyun; Cho, Eun Bin; Seok, Jin Myoung; Kim, Seok Jin; Kim, Kihyun; Jeon, Eun-Seok; Min, Ju-Hong; Kim, Byoung Joon
• Is Part Of: Amyloid. Volume 29:Number 4(2022)
• Page Start: 263
• Page End: 269
• Publication Date: 2022-10-02
• Subjects: AL amyloidosis -- generalised autonomic failure -- composite autonomic severity score -- prognosis -- survival; Amyloidosis -- Periodicals; 616.3995
• DOI: 10.1080/13506129.2022.2082866
• Languages: English
• ISSNs: 1350-6129

Abstract

Abstract: Background: In the present study, it was investigated whether autonomic dysfunction could predict prognosis in light-chain (AL) amyloidosis patients. Patients and methods: Seventy-two patients with biopsy-proven AL amyloidosis were included and underwent an autonomic function test (AFT) between January 2016 and June 2019. Autonomic failure was evaluated using the Composite Autonomic Severity Score (CASS). Survival curves and the three-year overall survival (OS) rate were estimated using the Kaplan–Meier curve, and the Cox proportional hazards regression method was used to evaluate the variables that influenced survival. Results: Autonomic dysfunction was observed in 69 (96%) patients with AL amyloidosis, and the three-year OS rate was 67%. Generalised autonomic failure (GAF) was observed in 31 (43%) patients. In the Kaplan–Meier curve, the three-year OS rates in patients with sudomotor dysfunction or GAF were lower than that in control patients (35 vs. 84%, and 33 vs. 81%, respectively). In Cox proportional hazards regression model, female, bone marrow plasma cell percentage, left ventricular systolic dysfunction, and GAF were significant independent variables associated with survival. Conclusion: The results of this study indicate that GAF on the AFT is an independent adverse prognostic factor for survival in AL amyloidosis patients.