Near-infrared heptamethine cyanine dye-based nanoscale coordination polymers with intrinsic nucleus-targeting for low temperature photothermal therapy. (October 2020)

• Record Type: Journal Article
• Authors: Jiang, Zhenqi; Yuan, Bo; Wang, Yinjie; Wei, Zhenni; Sun, Shan; Akakuru, Ozioma Udochukwu; Li, Yong; Li, Juan; Wu, Aiguo
• Is Part Of: Nano today. Volume 34(2020)
• Publication Date: 2020-10
• Subjects: Nanoscale coordination polymer -- Photothermal therapy -- Nucleus targeting -- Near-infrared -- Heptamethine cyanine; Nanotechnology -- Periodicals; Nanosciences -- Périodiques; 620.505
• DOI: 10.1016/j.nantod.2020.100910
• Languages: English
• ISSNs: 1748-0132

Abstract

Graphical abstract: Intrinsic nucleus-targeting organic-inorganic hybridization nanomaterials: nano coordination polymers self-assembly from newly designed HI-4COOH and Hf 4+ with high photothermal conversion efficiency and nucleus-targeting for low power density and temperature photothermal therapy. Highlights: First nanoscale coordination polymer (NCP) that shows both intrinsic nucleus-targeting and strong near-infrared absorption. Significant improvement of antitumor efficacy under low power density and temperature in vitro and in vivo . The biocompatible NCP could be completely cleaned up within 14 days in vivo . Abstract: Effective photothermal therapy (PTT) under low temperature (< 50 °C) and power density (< 0.4 W/cm 2 ) avoiding the damage of skin and normal organs. Here, we report a novel heptamethine cyanine dye-based nanoscale coordination polymer (NCP), Hf-HI-4COOH, as an exceptionally effective photosensitizer for nucleus-targeting low temperature PTT. Hf-HI-4COOH shows strong near-infrared absorption and high photothermal conversion efficiency (39.51 %). Further, it exhibits intrinsic nucleus-targeting property and cell inhibition under low power density in vitro . Moreover, the long blood circulation, high tumor accumulation, and nucleus-targeting contribute to significant inhibition of breast tumors in tumor-bearing mice under low temperature (48 °C) and power density (0.3 W/cm 2 ) without obvious toxicity. In general, we establish a nucleus-targeting Hf-HI-4COOH for enhanced PTT with low temperature and power density.