Bisphenol S induced epigenetic and transcriptional changes in human breast cancer cell line MCF-7. (March 2019)

• Record Type: Journal Article
• Authors: Huang, Wei; Zhao, Chao; Zhong, Huan; Zhang, Shoudong; Xia, Yiji; Cai, Zongwei
• Is Part Of: Environmental pollution. Volume 246(2019)
• Page Start: 697
• Page End: 703
• Publication Date: 2019-03
• Subjects: Bisphenol S -- DNA methylation -- Gene expression profiling -- Breast cancer cell; Pollution -- Periodicals; Pollution -- Environmental aspects -- Periodicals; Environmental Pollution -- Periodicals; Pollution -- Périodiques; Pollution -- Aspect de l'environnement -- Périodiques; Pollution -- Effets physiologiques -- Périodiques; Pollution; Pollution -- Environmental aspects; Periodicals; Electronic journals; 363.73
• DOI: 10.1016/j.envpol.2018.12.084
• Languages: English
• ISSNs: 0269-7491

Abstract

Abstract: In recent years, concerns about using Bisphenol A (BPA) in daily consume products and its effects in many chronic human diseases have prompted the removal of BPA. However, the widely used BPA alternatives, including Bisphenol S (BPS), have a high structural similarity with BPA, suggesting that they may have similar biological effects towards human beings. Indeed, BPS was also found to have endocrine-disrupting effects. Epigenetic mechanism was reported to be involved in BPA-induced biological effects in both in vitro and in vivo models. However, there is no assessment on whether BPS could cause epigenetic changes. In this work, we investigated the possible epigenetic effects of BPS that might induce in human breast cancer cell line MCF-7. We found that BPS could change DNA methylation level of transposons. Besides, methylation status in promoter of breast cancer related genes CDH1, SFN, TNFRSF10C were also changed, which implied that BPS might play a role in the development of breast cancer. Gene expression profiling showed that some genes related to breast cancer progression were upregulated, including THBS4, PPARGC1A, CREB5, COL5A3 . Gene ontology (GO) analysis of the differentially expressed genes revealed the significantly changes in PI3K-Akt signaling pathway and extracellular matrix, which were related to the proliferation, migration and invasion of breast cancer cells. These results illustrated that BPS exposure might play roles in the progression of breast cancer. Graphical abstract: Image 1 Highlights: BPS exposure induced alterations of DNA methylation level in specific transposons. BPS exposure changed methylation status in promoter of breast cancer related genes. BPS changed expression of genes related to breast cancer development. Abstract : Changes in DNA methylation status and gene expression patterns induced by BPS exposure might play roles in the promotion of breast cancer.