CHANGES IN SOCIOECONOMIC STATUS ACROSS THE LIFE COURSE AND DEMENTIA ONSET IN JAPAN GERONTOLOGICAL EVALUATION STUDY. (8th November 2019)

• Record Type: Journal Article
• Authors: Sakaniwa, Ryoto; Sakaniwa, Ryoto; Shirai, Kokoro; iso, hiroyasu; Kondo, Katsunori
• Is Part Of: Innovation in aging. Volume 3(2019)Supplement 1
• Page Start: S191
• Page End: S191
• Publication Date: 2019-11-08
• Subjects: Aging -- Periodicals; Gerontology -- Periodicals; 612.67
• DOI: 10.1093/geroni/igz038.686
• Languages: English
• ISSNs: 2399-5300

Abstract

Abstract: Socioeconomic status (SES) is associated with dementia onset, but its transition throughout the life-course is poorly understood. In a prospective cohort of 40, 041 participants, aged over 65 years without dementia, we identified ten optimal classifications of life-course SES transitions and their associated impact on dementia. Our results showed a clear significant dose-response pattern with the highest risk of dementia from 1) impoverished SES throughout, 2) impoverished childhood SES with normal adult SES, 3) impoverished adult SES with self-employed in adulthood, 4) high educated with poor adult SES, 5) never having a job, 6) low educated but high SES (self- employed), 7) technician, 8) high educated with poor adult SES, 9) average SES throughout, and 10) high SES throughout. These results suggest that life-course SES history is strongly associated with dementia risk and did not interact with single scale measurement. Further causal pathways and theories are relevant for disease modification.