CELL NON-AUTONOMOUS SEROTONIN SIGNALING MEDIATES STRESS RESISTANCE AND LONGEVITY. (8th November 2019)

• Record Type: Journal Article
• Authors: Leiser, Scott; Miller, Hillary; Huang, Shijiao
• Is Part Of: Innovation in aging. Volume 3(2019)Supplement 1
• Page Start: S730
• Page End: S730
• Publication Date: 2019-11-08
• Subjects: Aging -- Periodicals; Gerontology -- Periodicals; 612.67
• DOI: 10.1093/geroni/igz038.2676
• Languages: English
• ISSNs: 2399-5300

Abstract

Abstract: The ability of organisms to perceive and respond to their environment is crucial to their long-term survival. Recent studies in model organisms identify signaling pathways that perceive environmental stress and cell non-autonomously modify systemic physiology. These pathways often originate in the neurons, where key cells monitor the external environment for changes including food availability, air-quality, and the presence of dangerous toxins. Our previous work identified a key role for serotonin signaling in the induction of flavin-containing monooxygenase-2 (fmo-2) downstream of hypoxic signaling. fmo-2 expression is necessary and sufficient to promote stress resistance and longevity downstream of multiple genetic pathways, making it a useful tool for identifying key components of these pathways. Our current data defines environments, pathways, and signaling molecules that induce fmo-2 and subsequently increase lifespan. Our resulting data define key roles for serotonin signaling and fmo-2 that rely upon the perception of oxygen and food.