Insulin plant (Costus pictus) extract improves insulin sensitivity and ameliorates atherogenic dyslipidaemia in fructose induced insulin resistant rats: Molecular mechanism. (August 2015)

• Record Type: Journal Article
• Authors: Ashwini, S.; Bobby, Zachariah; Joseph, Manoj; Jacob, Sajini Elizabeth; Padmapriya, Ramamoorthy
• Is Part Of: Journal of functional foods. Volume 17(2015)
• Page Start: 749
• Page End: 760
• Publication Date: 2015-08
• Subjects: Costus pictus -- Insulin resistance -- Low-grade inflammation -- Leptin -- Resistin -- Insulin plant; Quercetin (PubChem CID: 5280343) -- Isoquercetin (PubChem CID: 5280804) -- Kaempferol (PubChem CID: 5280863) -- Astragalin (PubChem CID: 5282102); Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2015.06.024
• Languages: English
• ISSNs: 1756-4646

Abstract

Highlights: C. pictus improves insulin sensitivity via anti-oxidant and anti-inflammatory effects. Modulates molecules involved in stress sensitive signalling cascade. Down-regulates expression of pro-inflammatory cytokines. Ameliorates leptin resistance; decreases plasma resistin and homocysteine levels. Prevents emergence of atherogenic dyslipidaemia. Abstract: The preventative effect of insulin plant ( Costus pictus ) leaf extract on hyperglycaemia, insulin sensitivity and dyslipidaemia in fructose-fed insulin resistant rats was investigated in the present study, further the possible underlying mechanism was also explored. It was observed that under insulin resistant condition this plant extract decreases hyperinsulinaemia by improving insulin sensitivity at the peripheral level through its antioxidant and anti-inflammatory effects. At molecular level decreased activation of molecules involved in stress sensitive signalling cascade and down regulation of pro-inflammatory cytokines were noticed. Furthermore the effects of this plant extract on adipokine profile and plasma homocysteine were evaluated. The possible active components responsible for the beneficial effect exerted by this plant extract have also been identified and quantified. To the best of our knowledge this is the first study on insulin plant extract on the aforementioned animal model.