Very Late Relapse in Pediatric Acute Myeloid Leukemia: A Case Report and Brief Literature Review. Issue 6 (August 2021)

• Record Type: Journal Article
• Authors: Unis, Graham D.; VanderVeen, Nathan; Fletcher, Matthew; Vasquez, Robert J.
• Is Part Of: Journal of pediatric hematology/oncology. Volume 43:Issue 6(2021)
• Publication Date: 2021-08
• Subjects: very late relapse -- acute myeloid leukemia -- donor leukocyte infusion -- stem cell transplant; Pediatric hematology -- Periodicals; Tumors in children -- Periodicals; 618.9215
• DOI: 10.1097/MPH.0000000000001989
• Languages: English
• ISSNs: 1077-4114

Abstract

Abstract : Acute myeloid leukemia (AML) is a heterogenous group of diseases affecting ~500 children in the United States annually. With current therapy, 90% of these children will obtain complete remission. However, 30% to 40% of these patients will relapse, most commonly within the first 3 years. Very late relapses, defined as relapse occurring >5 years after complete remission, are rare, accounting for 1% to 3% of relapses. We describe a patient with AML harboring an AFDN/KMT2A translocation who relapsed 12 years after matched sibling stem cell transplant, provide a brief review of the relevant literature, and describe proposed mechanisms to explain very late relapse AML.