Dysfunctional Immune System Reconstitution After Rituximab Exposure In Utero. Issue 4 (May 2021)

• Record Type: Journal Article
• Authors: Clark, Rebecca; Lindsey, Diana; Whiteway, Susan; Mikita, Cecilia; Lieuw, Kenneth
• Is Part Of: Journal of pediatric hematology/oncology. Volume 43:Issue 4(2021)
• Publication Date: 2021-05
• Subjects: rituximab -- hypogammaglobulinemia -- neutropenia -- in utero exposure; Pediatric hematology -- Periodicals; Tumors in children -- Periodicals; 618.9215
• DOI: 10.1097/MPH.0000000000001871
• Languages: English
• ISSNs: 1077-4114

Abstract

Abstract : Rituximab is an antibody that binds to B-lymphocytes and is increasingly used during pregnancy. As an immunoglobulin G, it will transfer across the placenta. Previous case reports describe a diversity of clinical presentations in neonates born following rituximab exposure in utero. Our case is the first to offer the long-term experience in the care of an infant with severe neutropenia and prolonged profound hypogammaglobulinemia and class-switching B cell defect after in utero rituximab exposure.