Surgical outcome in patients with MRI-negative, PET-positive temporal lobe epilepsy. (July 2015)

• Record Type: Journal Article
• Authors: Yıldırım Capraz, Irem; Kurt, Gökhan; Akdemir, Özgür; Hirfanoglu, Tugba; Oner, Yusuf; Sengezer, Tugba; Atay Kapucu, Lütfiye Ozlem; Serdaroglu, Ayse; Bilir, Erhan
• Is Part Of: Seizure. Volume 29(2015)
• Page Start: 63
• Page End: 68
• Publication Date: 2015-07
• Subjects: AED antiepileptic drugs -- ATL anterior temporal lobectomy -- AVM arteriovenous malformation -- CD cortical dysplasia -- CI confidence interval -- EEG electroencephalography -- FC febrile convulsion -- FDG-PET fluorodeoxyglucose positron emission tomography -- HM hypometabolism -- HS hippocampal sclerosis -- IED interictal epileptiform discharge -- MRI magnetic resonance imaging -- MTS mesial temporal sclerosis -- SGTCS secondary generalized tonic-clonic seizures -- TLE temporal lobe epilepsy; Medication-refractory epilepsy -- Temporal lobe epilepsy -- Epilepsy surgery -- Electroencephalography -- Magnetic resonance imaging -- Fluorodeoxyglucose positron emission tomography; Epilepsy -- Periodicals; Epilepsy -- Periodicals; Seizures -- Periodicals; Épilepsie -- Périodiques; Electronic journals; Electronic journals; 616.853
• DOI: 10.1016/j.seizure.2015.03.015
• Languages: English
• ISSNs: 1059-1311

Abstract

Highlights: Surgical outcomes of MRI−, PET+ TLE patients are similar to those of MTS patients. HM on PET is a good predictor for surgical outcome in patients with normal MRI. More than 2/3 of MRI−, PET+ patients with TLE are seizure-free. Abstract: Purpose: The purpose of this study was to determine the long-term surgical outcomes of magnetic resonance imaging (MRI)-negative, fluorodeoxyglucose positron emission tomography (FDG-PET)-positive patients with temporal lobe epilepsy (TLE) and compare them with those of patients with mesial temporal sclerosis (MTS). Methods: One hundred forty-one patients with TLE who underwent anterior temporal lobectomy were included in the study. The surgical outcomes of 24 patients with unilateral temporal hypometabolism on FDG-PET without an epileptogenic lesion on MRI were compared with that of patients with unilateral temporal hypometabolism on FDG-PET with MTS on MRI ( n = 117). The outcomes were compared using Engel's classification at 2 years after surgery. Clinical characteristics, unilateral interictal epileptiform discharges (IEDs), histopathological data and operation side were considered as probable prognostic factors. Results: Class I surgical outcomes were similar in MRI-negative patients and the patients with MTS on MRI (seizure-free rate at postoperative 2 years was 79.2% and 82% in the MRI-negative and MTS groups, respectively). In univariate analysis, history of febrile convulsions, presence of unilateral IEDs and left temporal localization were found to be significantly associated with seizure free outcome. Multivariate analysis revealed that independent predictors of a good outcome were history of febrile convulsions and presence of unilateral IEDs. Conclusion: Our results suggest that epilepsy surgery outcomes of MRI-negative, PET positive patients are similar to those of patients with MTS. This finding may aid in the selection of best candidates for epilepsy surgery.